![]() We assessed 15 patients with treatment-resistant depression at four different time-points throughout the entire course of an ECT protocol and 10 healthy participants at two functional neuroimaging examinations. Longitudinal intralimbic and limbic-prefrontal networks connectivity study. To assess sequential changes in limbic and prefrontal FC during the course of ECT and their impact on clinical response. more Although current models of depression suggest that a sequential modulation of limbic and prefrontal connectivity is needed for illness recovery, neuroimaging studies of electroconvulsive therapy (ECT) have focused on assessing functional connectivity (FC) before and after an ECT course, without characterizing functional changes occurring at early treatment phases. Images were preprocessed with the standard pipeline of voxel-based morphometry studies using Statistical Parametric Mappi.Īlthough current models of depression suggest that a sequential modulation of limbic and prefront. We performed a mega-analysis pooling structural MRI scans from the Obsessive-compulsive Brain Imaging Consortium and assessed whole-brain voxel-wise structural covariance of 4 striatal regions (dorsal and ventral caudate nucleus, and dorsal-caudal and ventral-rostral putamen) and 2 amygdalar nuclei (basolateral and centromedial-superficial). Altered structural covariance has been described in patients with different psychiatric disorders, including OCD, but to our knowledge, alterations within frontostriatal and frontoamygdalar circuits have not been explored. However, structural covariance, or volumetric correlations across distant brain regions, also provides network-level information. ![]() more Frontostriatal and frontoamygdalar connectivity alterations in patients with obsessive-compulsive disorder (OCD) have been typically described in functional neuroimaging studies. Frontostriatal and frontoamygdalar connectivity alterations in patients with obsessive-compulsive.
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